7/1/2005 · One approach underutilized in the assessment of presynaptic ethanol effects is in vivo systems analysis; this arises largely because of the complexities of the CNS circuitry and related uncertainty of remote ethanol effects, but also because of difficulties in the electrophysiological recording of neurons in vivo with the adequate resolution (and impulse block with TTX) of mPSCs required to.
These new findings suggest that future analyses of synaptic effects of ethanol should attempt to ascertain the role of presynaptic terminals and their involvement in alcohol’s behavioral actions. Other future directions should include an assessment of ethanol’s effects on presynaptic signal transduction linkages and on the molecular machinery of transmitter release and exocytosis in general.
Request PDF | The tipsy terminal: Presynaptic effects of ethanol | Considerable evidence suggests that the synapse is the most sensitive CNS element for ethanol effects . Although most alcohol …
These new findings suggest that future analyses of synaptic effects of ethanol should attempt to ascertain the role of presynaptic terminals and their involvement in alcohol’s behavioral actions….
1/25/2006 · They showed that ethanol administration could both increase and decrease the probability of release of different transmitters from synaptic terminals. The effects of ethanol on synaptic terminals could often be correlated with important behavioral or developmental actions of alcohol.
They showed that ethanol administration could both increase and decrease the probability of release of different transmitters from synaptic terminals. The effects of ethanol on synaptic terminals could often be correlated with important behavioral or developmental actions of alcohol.
Alcohol use disorder is the outcome of both genetic and environmental influences and their interaction via epigenetic mechanisms. The neurotransmitter glutamate is an important regulator of reward circuits and implicated in adaptive changes induced by ethanol intake. … Presynaptic Terminals / drug effects * … Presynaptic Terminals / metabolism, 2/1/2006 · Although ethanol appeared to enhance both presynaptic and postsynaptic parameters of sIPSCs, recorded in the absence of TTX, the enhancement of sIPSC frequency was the most robust effect of ethanol and, notably, blockade of GABAB receptors only facilitated the effect of ethanol on sIPSC frequency (Ariwodola and Weiner, 2004). Taken together, these studies suggest that acute.
This article presents the proceedings of a symposium entitled The Tipsy Terminal: Presynaptic Effects of Ethanol (held at the annual meeting of the Research Society on Alcoholism, in Santa …
